Muse MSCs
The future of the stem cell field has been with us this whole time in the form of Mesenchymal Stem Cells (MSCs) that express Embryonic stem cell (ESCs) markers. Within all naturally occurring MSC populations regardless of the tissue source, there exist a 1-3% sub population of MSCs that express pluripotent ESCs markers. These markers include Oct-4, Sox-2 and Nanog as well as Tra-1-60, Tra-1-81, SSEA-1 (stage- specific embryonic antigen-1), SSEA-4, SSEA+3, alkaline phosphatase and even form embryoid bodies in vitro.
In 2010, I co-authored a paper that identified this special sub population found within umbilical cord derived MSCs. Note to Haris - Embed the full paper.
“UC-MSCs not only possess MSC properties but they exhibit properties to those attributed to ESCs. Specifically, UC-MSCs express human ESC markers Tra-1-60, Tra-1-81, SSEA-1 (stage- specific embryonic antigen-1), SSEA-4, SSEA+3, alkaline phosphatase and even form embryoid bodies in vitro. Additionally, UC-MSCs express the pluripotency markers Oct-4, Sox-2, and Nanog. These markers are up-regulated in undifferentiated human embryonic stem cells and have been shown to maintain pluripotency in self-renewing human ESC populations.”
Note - Sometimes in the field these cells are referred to a Multilineage Stress Endearing Cells or Muse MSCs due to the work performed by Dr. Dezawa in Japan on this MSC sub population. Kyle Cetrulo, the Perinatal Stem Cell Society and StemCell Athlete are not associated with Dr. Dezawa or Muse Cell Innovations in any way at all.
The ESC expressing MSC or Muse MSCs subpopulation also express HLA-G at 90%. HLA-G, or Human Leukocyte Antigen-G, is a non-classical immune protein involved in immune tolerance, most notably between a mother and fetus during pregnancy. It also plays a significant role in immune evasion and in transplant rejection. The high expression of HLA-G enable this 1-3% subpopulation to remain in the body for up to 6 months compared to 7-14 days for the rest of the MSC population.
The expression of the ESC markers on this subpopulation of MSCs or Muse MSCs enables these cells to directly intregrate into the damaged tissue and become new cells. In fact, microarray studies confirm that UC- MSCs express markers of all three primordial germ layers independent of passage. This is a huge regenerative advantage over the rest of the MSC cells.
Muse MSCs are the future of the stem cell field because these stem cells have the safety profile of MSCS which are long established as safe with over 30,000 peer reviewed papers and the potency of iPSCs.
For more information on Muse MSC or to bring to your clinic please contact:
kyle.cetrulo@perinatalstemcells.com
What Makes Muse Cells Unique
Muse cells are a naturally existing subset of mesenchymal stem cells (MSCs) with exceptional properties:
Pluripotent yet Non-Tumorigenic
Capable of differentiating into multiple cell types without the risk of tumor formation.
Immune Privileged
Can be administered across HLA mismatches without immunosuppression, a breakthrough that challenges conventional immunology.
Endogenous & Ethically Sourced
Found naturally in adult and perinatal tissues — no genetic manipulation required.
Self-Homing Ability
Everything we do is built around understanding your needs and helping you succeed—because when you thrive, so do we.
Long-Term Integration
They not only repair tissues but also remain functional for years, continuing to produce healing factors.
